Car T Cells Senescence

The car t cells worked in mouse models of liver and lung cancers and liver fibrosis the team reported in nature.

Car t cells senescence. Senescence is a double edge sword the study s co corresponding author scott lowe. Senolytic car t cells reverse senescence associated pathologies entry into senescence imposes a stable arrest of the cell cycle preventing old damaged or precancerous cells from. T cell senescence has been recognized to play an immunosuppressive role in the aging population and cancer patients. Car t cells target senescence marker ameliorate cancer fibrosis.

Strategies dedicated to preventing or reversing replicative and premature t cell senescence are required to increase the lifespan of human beings and to reduce the morbidity from cancer. Car t cells that target upar extend the survival of mice with lung adenocarcinoma that are treated with a senescence inducing combination of drugs and restore tissue homeostasis in mice in which. When injected into a mouse model of lung adenocarcinoma treated with a senescence inducing cancer therapy the upar car t cells substantially decreased senescent lung tumour cells and extended. We identify the urokinase type plasminogen activator receptor upar 11 as a cell surface protein that is broadly induced during senescence and show that upar specific car t cells efficiently ablate senescent cells in vitro and in vivo.

Car t cells red attacking senescent cells green in a mouse model of liver fibrosis. Then they designed car t cells that recognize upar and tested them in several different mouse models of senescence related diseases including cancer and liver fibrosis. The team s next step will be to determine whether the upar directed car t cells can effectively combat other senescence related diseases including atherosclerosis diabetes and osteoarthritis. Chimeric antigen receptor car t cells that target an antigen produced by senescent cells are potential therapies in diseases of aging and chronic tissue damage such as diabetes and fibrosis.

As well the car t cells improved survival in mouse models of lung cancer when given along with drugs previously shown to induce senescence in this cancer type.