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However car t cells could overcome this viral escape mechanism as the chimeric antigen receptor directly recognizes antigen without mhc i restriction 75 104.
Car t cell therapy advantages. The major advantage is that car t cell therapy is a single infusion that usually requires at the most two weeks of inpatient care and then it s done. Because aggressive chemotherapy is not used most patients have a much more rapid recovery than after stem cell transplants in which aggressive chemotherapy is used. In contrast newly diagnosed non hodgkin s lymphoma and childhood leukemia patients usually need at least six months or more of chemotherapy. Partial response means there was some reduction in the extent of the cancer.
What s the success rate of car t cell therapy for lymphoma. But once that is over the patient shouldn t need another treatment. There was a strong signal for efficacy of car t cell therapy in patients with cd19 hematologic malignancies and no overall signal in solid tumor trials published to date. A complete response means there were no signs of cancer.
An infused patient usually needs to remain inpatient at a hospital for clinical monitoring for about a week. Reported that cd4 receptor based car t cells have a decay. Further the long term persistence of car t cell therapy promises prolonged therapeutic benefit 85 105. Over 80 percent of patients who received yescarta in clinical trials experienced either a complete or partial response.
One of the major advantages of car t cell therapy is the short treatment time needed administered with a single infusion that may require at the most two weeks of inpatient care and then it s done.
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